Details.
Generation of genetically modified mice for gene function analysis, disease model development, or recombinant protein production. Includes Knock-In or Knock-Out models, constitutive or conditional, using embryonic stem cell genetic modification or CRISPR/Cas9 approaches. Support is provided from project concept and targeting strategy through obtaining the desired model. Lines are established in the Cochin Institute Animal Facilities with SPF or SOPF status.