Details.
Off-label immunotherapy with Humira for reproductive problems associated with increased tumour necrosis factor alpha or increased uterine immune activity, including recurrent miscarriage or repeated IVF failure. The treatment involves subcutaneous injections under the skin of the stomach or thigh, given two weeks apart, with up to a maximum of four injections prescribed for reproductive problems. A negative TB blood test is required before starting treatment. Patients should avoid live or attenuated vaccines and contact with people who have contagious illnesses, and should report specified symptoms to their doctor. The treatment is described as controversial, with insufficient evidence currently available to demonstrate its effectiveness.